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Olympus CKX53 – an inverted microscope for live cell applications

The very best image quality can be obtained by combining the Olympus CKX53 microscope with large sensor cameras (DSLRs with full-frame or APS-C sensors). Coupled with our LM microscope adapters, these state-of-the-art cameras deliver exceptional resolution, dynamic range and light sensitivity.

The Olympus CKX53 inverted research microscope was developed to address a variety of cell culture needs, including live cell observations, sample preparation, image capture and fluorescence observation. Thanks to its UV-resistant coating, the instrument can also be used in tandem with UV light sterilisation on a sterile workbench. Weighing in at just 7 kg, the Olympus CKX53 is easy to move with just one hand by holding the neck of its observation tube. The dependable Olympus UIS-2 objectives (universal infinity-corrected) guarantee high-quality images.

Inverse research microscope Olympus CKX53

The Olympus CKX53 can be used for bright field, phase contrast (entry-level and standard configurations) and fluorescence imaging (various illumination systems and high quality fluorescence filter modules are available). The unique integrated Phase Contrast (iPC) system from Olympus simplifies and accelerates observation workflow by dispensing with the need to change or centre the ring slit repeatedly. In addition, the novel Olympus inversion contrast (IVC) technique enables three-dimensional images of objects of any shape or transparency using 10x objectives. A 2x objective, which, together with the aperture diaphragm slider, achieves a field of view of 22 mm over areas of up to 11 mm in diameter, allows even transparent objects in the sample to be clearly identified.

To make it suitable for photomicrography applications, the Olympus CKX53 is equipped with a trinocular tube with a dovetail ring. With our LM digital adapters, most DSLR and system cameras can be attached to the microscope in a few easy steps.

LM microscope adapter combines DSLR with microscope

From an ergonomic perspective, the CKX53 is well designed, especially considering the eyepieces that are inclined at a 45-degree angle and the handy positioning of its control elements. Illumination is provided by an LED light source, and thanks to the large working distance, sample containers of up to 190 mm in height can be examined. A number of stage extensions are available as well. The revolving four-objective nosepiece is operated manually.


Fitting the microscope to digital single-lens reflex (DSLR), system or C-mount cameras is easy with our LM digital SLR adapters, which feature a plan achromatic optical system. Our products make it possible to capture top-quality microscope images. To help you select the adapter that is right for your camera, we have set up an online configurator on our website. You can also email us – ideally with attached photographs of your microscope.

Modern DSLR and system cameras offer the latest technology and are generally very well suited for microscopy applications. Most of them can be controlled remotely via PC/Mac. Because of their high sales volumes, they offer an excellent price/performance ratio compared to special-purpose microscope cameras.

Features of top DSLR and system cameras:
- Large, powerful full-frame sensors (36 x 24 mm)
- Sensor resolution of 50 megapixels
- High light sensitivity (ISO 100,000+)
- Extensive dynamic range (up to 14 aperture stops/f-stops)
- Short exposure times (1/8000 second):
- Full/Ultra HD (4k) video function
- Live video capture on external monitors in ultra HD quality

In most cases, these cameras are significantly more powerful than microscope cameras with smaller sensors (1/2" or 2/3"). On our website you will find our current camera recommendations and a camera ranking which is specifically tailored to microscopy applications.

New LM Digital Adapter for: Nikon Z9 / Sony Alpha 1 / Sony FX3 Cinema Line / Sony Alpha 9 II (ILCE-9M2) / Sony Alpha 9 / Nikon D6 / Canon EOS R3 / Sony Alpha 7R IV / Canon EOS R5 / Sony Alpha 7S II / Sony Alpha 7R III / Canon EOS R6 / Nikon Z6 / Nikon Z6II / Sony Alpha 7R II / Nikon Z7 / Nikon Z7II / Canon EOS R / Canon EOS Ra (Astro) / Nikon Z5 / Sony Alpha 7C / Canon EOS RP / Sony Alpha 7S / Canon EOS 1D X Mark III / Nikon Z50 / Nikon D850 / Canon EOS 1D X Mark II / Nikon D780 / Sony Alpha 7III / Nikon D5 / Sony Alpha 6600 / Sony Alpha 6400 / Sony Alpha 6100 / Sony ZV-E10 / Canon EOS 1D X / Nikon D4s / Olympus OM-D E-M5 III / Canon EOS 90D / Canon EOS 5D Mark IV / Nikon D4 / Nikon D750 / Canon EOS 6D Mark II / Fujifilm X-T4 / Fujifilm X-T3 / Sony Alpha 6300 / Sony Alpha 6500 / Nikon D500 / Nikon D810 / Nikon D800 / Canon EOS M6 Mark II / Nikon D800E / Nikon Df / Panasonic Lumix DC-G9 / Nikon D610 / Nikon D600 / Canon EOS 250D / Canon EOS 850D / Rebel T8i / Canon EOS 6D / Sony Alpha 99 II (SLT-A99 II) / Canon EOS M200 / Canon EOS 5DS R ( without low-pass filter) / Olympus OM-D E-M1 Mark II / Canon EOS 80D / Canon EOS 5DS / Canon EOS M50 / Sony Alpha 77 II / Canon EOS 70D / Nikon D7200 / Pentax K-1 Mark II / Canon EOS 200D / Canon EOS 800D / Rebel T7i / Canon EOS 77D / Canon EOS 5D Mark III / Canon EOS 60D / Sony Alpha 7R / Sony Alpha 7 / Nikon DS-Qi2 (Microscope Camera) / Olympus OM-D E-M5 II / Nikon D3x / Olympus OM-D E-M1 / Pentax KP / Nikon D3S / Canon EOS 750D / Rebel T6i / Canon EOS 760D / Rebel T6s / Canon EOS 5D Mark II / Nikon D7100 / Pentax K-5 / Canon EOS 1D Mark IV / Nikon D7000 / Canon EOS 7D Mark II / Canon EOS 600D / Rebel T3i / Canon EOS 650D / Rebel T4i / Canon EOS 700D / Rebel T5i / Canon EOS 2000D / Rebel T7 / Canon EOS 7D / Canon EOS 550D / Rebel T2i / Kiss X4 Digital / Canon EOS 1300D / EOS Rebel T6 / Canon EOS 4000D / Canon EOS 100D / Nikon DS-Ri2 (Microscope Camera) / Canon EOS 50D /