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Olympus CKX53 – an inverted microscope for live cell applications

The very best image quality can be obtained by combining the Olympus CKX53 microscope with large sensor cameras (DSLRs with full-frame or APS-C sensors). Coupled with our LM microscope adapters, these state-of-the-art cameras deliver exceptional resolution, dynamic range and light sensitivity.

The Olympus CKX53 inverted research microscope was developed to address a variety of cell culture needs, including live cell observations, sample preparation, image capture and fluorescence observation. Thanks to its UV-resistant coating, the instrument can also be used in tandem with UV light sterilisation on a sterile workbench. Weighing in at just 7 kg, the Olympus CKX53 is easy to move with just one hand by holding the neck of its observation tube. The dependable Olympus UIS-2 objectives (universal infinity-corrected) guarantee high-quality images.

Inverse research microscope Olympus CKX53

The Olympus CKX53 can be used for bright field, phase contrast (entry-level and standard configurations) and fluorescence imaging (various illumination systems and high quality fluorescence filter modules are available). The unique integrated Phase Contrast (iPC) system from Olympus simplifies and accelerates observation workflow by dispensing with the need to change or centre the ring slit repeatedly. In addition, the novel Olympus inversion contrast (IVC) technique enables three-dimensional images of objects of any shape or transparency using 10x objectives. A 2x objective, which, together with the aperture diaphragm slider, achieves a field of view of 22 mm over areas of up to 11 mm in diameter, allows even transparent objects in the sample to be clearly identified.

To make it suitable for photomicrography applications, the Olympus CKX53 is equipped with a trinocular tube with a dovetail ring. With our LM digital adapters, most DSLR and system cameras can be attached to the microscope in a few easy steps.

LM microscope adapter combines DSLR with microscope

From an ergonomic perspective, the CKX53 is well designed, especially considering the eyepieces that are inclined at a 45-degree angle and the handy positioning of its control elements. Illumination is provided by an LED light source, and thanks to the large working distance, sample containers of up to 190 mm in height can be examined. A number of stage extensions are available as well. The revolving four-objective nosepiece is operated manually.


Fitting the microscope to digital single-lens reflex (DSLR), mirrorless interchangeable-lens cameras (MILC ), digital single-lens mirrorless (DSLM) or C-mount cameras is easy with our LM digital SLR adapters, which feature a plan achromatic optical system. Our products make it possible to capture top-quality microscope images. To help you select the adapter that is right for your camera, we have set up an online configurator on our website. You can also email us – ideally with attached photographs of your microscope.

Modern DSLR and single-lens mirrorless (DSLM) offer the latest technology and are generally very well suited for microscopy applications. Most of them can be controlled remotely via PC/Mac. Because of their high sales volumes, they offer an excellent price/performance ratio compared to special-purpose microscope cameras.

Features of top DSLR and single-lens mirrorless cameras (DSLM):
- Large, powerful full-frame sensors (36 x 24 mm)
- Sensor resolution of 61 megapixels or 240 megapixels with Pixel Shift technology
- High light sensitivity (ISO 400,000+)
- Extensive dynamic range (up to 15 aperture stops/f-stops)
- Short exposure times (1/8000 second) up to 1/32,000 seconds using the digital shutter
- 4K Ultra HD  or 8K Ultra HD video function
- Live video capture on external monitors in ultra HD quality

In most cases, these cameras are significantly more powerful than microscope cameras with smaller sensors (1/2" or 2/3"). On our website you will find our current camera recommendations and a camera ranking which is specifically tailored to microscopy applications.

New LM Digital Adapter for: Sony Alpha 9 III / Nikon Z9 / Nikon Z8 / Sony Alpha 7R V / Sony Alpha 1 / Sony Alpha 9 II (ILCE-9M2) / Sony FX3 Cinema Line / Sony Alpha 9 / Nikon D6 / Canon EOS R3 / Canon EOS R6 Mark II / Canon EOS R8 / Sony Alpha 7R IV / Canon EOS R5 / Sony Alpha 7S II / Sony Alpha 7S III / Sony Alpha 7R III / Canon EOS R6 / Nikon Z6 / Nikon Z6II / Sony Alpha 7R II / Nikon Z7 / Nikon Z7II / Canon EOS R / Canon EOS Ra (Astro) / Nikon Z5 / Sony Alpha 7C / Canon EOS RP / Sony Alpha 7S / Canon EOS R7 / Leica SL2-S / Canon EOS R10 / Canon EOS 1D X Mark III / Nikon Z50 / Nikon Z30 / Nikon Z fc / Nikon D850 / Canon EOS 1D X Mark II / Nikon D780 / Olympus OM-1 / Sony Alpha 7III / Olympus OM-D E-M1 Mark III / Canon EOS R100 / Sony Alpha 6700 / Nikon D5 / Sony Alpha 6600 / Fujifilm X-H2S / Fujifilm X-S10 / Fujifilm X-E4 / Fujifilm X-Pro3 / Olympus OM-D E-M1X / Sony Alpha 6400 / Sony Alpha 6100 / Sony ZV-E10 / Canon EOS 1D X / Nikon D4s / Olympus OM-D E-M5 III / Canon EOS 90D / Canon EOS 5D Mark IV / Nikon D4 / Nikon D750 / Canon EOS 6D Mark II / Fujifilm X-T4 / Fujifilm X-T3 / Sony Alpha 6300 / Sony Alpha 6500 / Nikon D500 / Nikon D810 / Nikon D800 / Canon EOS M6 Mark II / Nikon D800E / Nikon Df / Panasonic Lumix DC-G9 / Nikon D610 / Nikon D600 / Canon EOS 250D / Canon EOS 850D / Rebel T8i / Canon EOS 6D / Sony Alpha 99 II (SLT-A99 II) / Canon EOS M200 / Canon EOS 5DS R ( without low-pass filter) / Olympus OM-D E-M1 Mark II / Canon EOS 80D / Canon EOS M50 Mark II / Canon EOS 5DS / Canon EOS M50 / Sony Alpha 77 II / Canon EOS 70D / Nikon D7200 / Pentax K-1 Mark II / Canon EOS 200D / Canon EOS 800D / Rebel T7i / Canon EOS 77D / Canon EOS 5D Mark III / Canon EOS 60D / Sony Alpha 7R / Sony Alpha 7 / Nikon DS-Qi2 (Microscope Camera) / Olympus OM-D E-M5 II / Nikon D3x / Olympus OM-D E-M1 /